RESEARCH

Our main goal is to decipher how the cytoskeleton controls cancer via cross-talk with the transcriptional machinery.

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VICTORIA SANZ-MORENO LAB

The Sanz-Moreno lab works on understanding how the cytoskeleton and Rho GTPase signalling in cancer cells promotes tumour growth and dissemination. We are interested in better defining how Rho GTPase signals are translated via transcription factors into appropriate pro-tumorigenic responses.

The lab combines ‘OMICs’, state of the art microscopy in 3D matrices, molecular biology, animal models and digital pathology in patient tissues to identify molecular determinants driven by Rho GTPase signalling that correlate with cancer progression and metastatic potential. Furthermore, we aim to define how the cytoskeleton in cancer cells controls tumour cell-normal cell interactions.

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LATEST RESEARCH

MELANOMA PATIENT SECTIONS SHOW STAT3 ACTIVITY

MELANOMA CELLS AND ENDOTHELIAL CELLS

AMOEBOID CELLS AND THE MATRIX

MESENCHYMAL CELLS AND THE MATRIX

IMMUNOHISTOCHEMISTRY IN PATIENT SAMPLES SHOW HIGH CITED1 IN MESTASTASIS

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